Johannes M F G Aerts Selected Research

cyclophellitol

1/2019	Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.
5/2016	Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.

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Johannes M F G Aerts Research Topics

Disease

55	Gaucher Disease (Gaucher's Disease) 01/2022 - 07/2002
26	Fabry Disease (Fabry's Disease) 12/2021 - 01/2003
8	Inflammation (Inflammations) 01/2022 - 10/2005
8	Insulin Resistance 01/2019 - 02/2007
6	Type 2 Diabetes Mellitus (MODY) 10/2021 - 01/2009
6	Obesity 04/2021 - 02/2007
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 04/2012
4	Neoplasms (Cancer) 01/2020 - 05/2012
3	Parkinson Disease (Parkinson's Disease) 01/2022 - 12/2018
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2021 - 01/2020
3	Body Weight (Weight, Body) 10/2014 - 11/2009
3	Pain (Aches) 10/2011 - 10/2002
2	Niemann-Pick Diseases (Niemann Pick Disease) 11/2021 - 01/2020
2	Multiple Sclerosis 04/2021 - 04/2010
2	Globoid Cell Leukodystrophy (Krabbe Disease) 01/2020 - 01/2017
2	Fibrosis (Cirrhosis) 01/2020 - 01/2012
2	Disease Progression 01/2020 - 06/2011
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2019 - 04/2006
2	Infections 01/2019 - 06/2009
2	Nervous System Diseases (Neurological Disorders) 01/2019 - 01/2017
2	Atherosclerosis 07/2014 - 04/2010
2	Sandhoff Disease (Sandhoff's Disease) 01/2011 - 04/2006
2	Pathologic Processes 01/2009 - 02/2007
2	Renal Insufficiency (Renal Failure) 06/2007 - 08/2003
2	Necrosis 02/2007 - 10/2002
1	Neuroinflammatory Diseases 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Cutis Laxa 11/2020
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2020
1	Mannosidase Deficiency Diseases (Mannosidosis) 01/2020
1	Netherton Syndrome 01/2020
1	Atopic Dermatitis (Atopic Eczema) 01/2020
1	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Mucopolysaccharidoses 12/2018
1	Polyploidy 11/2018
1	Mucopolysaccharidosis VII (Sly Syndrome) 08/2017

Drug/Important Bio-Agent (IBA)

22	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 01/2004
22	EnzymesIBA 10/2021 - 07/2002
20	Glucosylceramides (Glucocerebrosides)IBA 01/2022 - 01/2004
13	LipidsIBA 04/2021 - 01/2003
12	GlycosphingolipidsIBA 01/2020 - 02/2007
9	chitotriosidaseIBA 03/2010 - 07/2002
8	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2004
7	GalactosidasesIBA 12/2021 - 10/2012
7	alpha-Galactosidase (Beano)IBA 01/2017 - 01/2003
7	ceramide glucosyltransferaseIBA 07/2011 - 02/2007
6	globotriaosylceramide (globotriosylceramide)IBA 12/2021 - 10/2004
6	AcidsIBA 11/2021 - 07/2004
6	GlucosidasesIBA 11/2019 - 01/2011
5	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 03/2007
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2003
5	Pharmaceutical PreparationsIBA 01/2017 - 06/2007
5	AntibodiesIBA 01/2012 - 10/2004
5	N- (5- adamantane- 1- yl- methoxy- pentyl)deoxynojirimycinIBA 01/2012 - 07/2004
5	Insulin (Novolin)FDA Link 01/2011 - 02/2007
4	sphingosyl beta-glucosideIBA 01/2022 - 04/2015
4	SphingolipidsIBA 01/2021 - 01/2009
4	imiglucerase FDA Link 12/2012 - 02/2007
3	globotriaosyl lysosphingolipidIBA 12/2021 - 10/2011
3	SphingomyelinsIBA 11/2021 - 01/2020
3	CholesterolIBA 03/2021 - 04/2012
3	CeramidesIBA 01/2021 - 12/2018
3	GlycolipidsIBA 01/2019 - 07/2004
3	ProteomeIBA 01/2017 - 10/2008
3	agalsidase beta FDA Link 02/2011 - 07/2007
2	Acid CeramidaseIBA 01/2022 - 04/2015
2	Lysergic Acid Diethylamide (LSD)IBA 12/2021 - 11/2021
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 11/2021 - 01/2020
2	cyclophellitolIBA 01/2019 - 05/2016
2	HydrolasesIBA 01/2017 - 08/2014
2	Mannose (D-Mannose)IBA 01/2017 - 04/2006
2	Biological ProductsIBA 01/2014 - 01/2008
2	agalsidase alfaIBA 07/2008 - 07/2007
2	AdiponectinIBA 03/2007 - 02/2007
2	Chemokine CCL18IBA 10/2006 - 01/2004
2	ChitinasesIBA 11/2005 - 10/2005
1	Starch (Cornstarch)IBA 10/2021
1	Amylases FDA Link 10/2021
1	ApolipoproteinsIBA 01/2021
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 11/2020
1	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA 01/2020
1	Polysaccharides (Glycans)IBA 01/2020
1	Serine Proteases (Serine Protease)IBA 01/2020
1	LDL CholesterolIBA 01/2020
1	sphingosine phosphorylcholineIBA 01/2020
1	conduritol epoxideIBA 01/2019
1	Mannose ReceptorIBA 01/2019
1	Actins (F Actin)IBA 01/2019
1	Iduronidase (alpha-L-Iduronidase)IBA 12/2018
1	cyclohexeneIBA 12/2018
1	EndocannabinoidsIBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2018
1	heparanaseIBA 08/2017

Therapy/Procedure

16	Enzyme Replacement Therapy 09/2020 - 10/2003
15	Therapeutics 01/2020 - 01/2003
4	Enzyme Therapy 11/2009 - 01/2003